Primary data associated with the manuscript "Parkinson’s VPS35[D620N] retromer lysosomal dysfunction induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B" (Prosenjit Pal, Matthew Taylor, Pui Yiu Lam, Francesca Tonelli, Chloe A. Hecht, Pawel Lis, Raja S. Nirujogi, Toan K. Phung, Emily A. Dickie, Mel Wightman, Thomas Macartney, Suzanne R. Pfeffer and Dario R. Alessi). These include raw immunoblotting data (annotated .tiff exports of Image Studio Lite Licor scans) with their quantitation (.xlsx files) and graphs with statistical analysis obtained using GraphPad Prism (.pzf files).