Introduction: Extraintestinal manifestations of Crohn's disease are common and result from the autoimmune inflammatory pathology extending into organs outside the gastrointestinal system, such as the hepatobiliary tree, pancreas, skin, eyes, and oral cavity. Case report: A 58-year-old male patient was referred to our Department due to severe abdominal pain. The patient's medical history shows that he has suffered from Crohn's disease for fifteen years. He had a resection of the terminal ileum in 2009. After that, he was treated because of constriction at the major duodenal papilla, and a bile duct prosthesis was inserted. For five years, the remission of the disease was maintained with azathioprine. Three months after stopping the therapy with azathioprine, he began to complain of upper abdominal pain in the back. After admission to our Department, an abdominal CT with contrast revealed changes in the pancreas. The leukocyte count was 30 × 10^9/L, the CRP level was 98 mg/L, and severe hypoalbuminemia was present at 22 g/L. The patient was transferred to the intensive care unit for further treatment. Conclusion: Crohn's disease is a systemic disease that may be associated with many extra-intestinal manifestations. For these reasons, it is crucial to understand the complexity of this disease, which necessitates a comprehensive approach to treating autoimmune disorders.