Abstract In our research, we evaluated the lipid profile of the blood plasma (total cholesterol, triglycerides, low-density lipoproteins, high-density lipoproteins) and the peculiarities of the dynamics of their changes in patients with chronic pancreatitis combined with hypothyroidism. The study of the comorbidity of these pathologies is a rather promising area of clinical gastroenterology and endocrinology. The study revealed the most pronounced signs of dyslipidemia in the group of patients with chronic pancreatitis combined with hypothyroidism. This confirms the close connection of these pathologies and requires further treatment correction. The results indicate the need for a more comprehensive study of the course and interaction of these diseases in order to avoid complications of these diseases in the future.

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