ABSTRACT The aim of this systematic review to evaluate the effect of diabetes on dental implants loss .Review authors searched 3 electronic databases; Pubmed, Cochrane and Lilacs: 11/10/2018, hand searched 11 journals till November 2018 and snowballing: 15/10/2018. Adult female and male patients above 18 years old, either completely or partially edentulous, maxillary and/or mandibular dental implants, restored by fixed or removable prosthesis, were included. Surgical modifications, drugs that affect bone density, like vitamin D and biphosphonates, were excluded. Diabetic patients, who are classified either controlled or uncontrolled were considered eligible. Review authors extracted data relevant to PECOT. Data was descriptively and statistically analyzed. 14 studies; 9 prospective and 5 retrospective studies, involving 1398 participants and 3282 implants, were included in this systematic review. 3 studies were included in the meta-analysis. Based on the results of implant loss 2 years following implant placement, implant therapy in diabetic patients seems to be possible. However, results should be taken with extreme cautions, since the quality of evidence is very low. Keywords: Diabetes mellitus, high blood sugar, Dental implants, Oral implants