Background: The incidence of various non-hematological malignancies is on the rise due to increasing awareness and effective screening programmes. An abnormal hematological parameters like anemia, leucocytosis, thrombocytosis may be the first manifestation in patients with non-hematological malignancies. The present study was conducted to detect the hematological abnormalities in patients with non-hematological malignancies and correlate these parameters with the stage of the disease. Materials And Methods: 100 cases of non-hematological malignancies were randomly seleted. Their blood samples were collected and examined. Observation And Results: Out of 100 patients, most of them were in the age group of 51-70years. among them 53% were males and 47% were females. Anemia was detected in 78%, leucocytosis was detected in 42% and thrombocytosis was found in 26% of patients. The incidence(93.1%) and severity(72.4%) of anemia increases with the advancing stage of the disease. The incidence of leucocytosis(51.7%) and thrombocytosis(44.8%) also increases with the advancing stage of the disease. Conclusion: The present study showed a definite association of hematological abnormalities like anemia, leucocytosis and thrombocytosis in patients with various non-hematological malignancies. These parameters increases with the advancing stage of the disease. Hence early detection and proper intervention can help in better patient outcome and improvement in quality of life.