Over a decade fecal microbiota transplantation emerged as the best treatment approach in the therapy of dysbiosis-related diseases by improving or restoring the composition of the recipient's gut microbiota. FMT is highly recommended and effective in case of recurrent or refractory Clostridioides difficile infection (CDI) WITH 90% of cure rates. Despite the anticipated therapeutic advantages of FMT, the precise mechanism of action of FMT is not well understood. FDA released a safety alert regarding the potential life-threatening infections that may occur after a fecal microbiota transplant. Several RCT and clinical trials are performing on the FMT to understand the efficacy and safety in various other gut-related disorders. In this Review, we emphasized the mechanism of action, indications and contraindications, complications, and management of FMT in other diseases. Keywords: Fecal Microbiota Transplantation, Clostridium Infections, Gastrointestinal diseases.