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Divergent effects of aging across human brain regions at single cell resolution

descriptionPublicationkeyboard_double_arrow_right Article 05 Apr 2023Publisher:Zenodo
Authors: Megan Duffy; Jinhui Ding; Rebekah Langston; D. Thad Whitaker; J. Raphael Gibbs; Mark R. Cookson;

doi: 10.5281/zenodo.7847419 , 10.5281/zenodo.7803698 , 10.5281/zenodo.7847456

Divergent effects of aging across human brain regions at single cell resolution

Abstract

Single nuclear RNA-sequencing was performed on human post-mortem brain tissue from four distinct nuclei that have implications for neurodegenerative diseases, including Alzheimer's and Parkinson’s diseases. Younger, aged 20s to 30s, and middle-aged and older, aged 60s to 80s, adults were used to identify changes in cell populations and transcriptomes during aging.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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