The management of chronic myelogenous leukemia during pregnancy requires balancing the health of both mother and fetus. We report a case of a 22-yearold female who was diagnosed with chronic myelogenous leukemia (CML) at 24 weeks gestation and who had an atypical chromosome t(9;22;11) (q34;q11.2;q13) translocation. She was managed with PEG-IFNa through the remainder of the pregnancy and the disease remained stable; she delivered a normal male child. Treatment with dasatinib was initiated 1 week after delivery on patient’s request and she went into complete hematologic remission after 1 month of therapy. We discuss the course of the disease and various treatment modalities available for CML during pregnancy.