<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

FORMULATION AND IN VITRO CHARACTERIZATION OF IBRUTINIB EXTENDED RELEASE TABLETS

Name: FORMULATION AND IN VITRO CHARACTERIZATION OF IBRUTINIB EXTENDED RELEASE TABLETS
Creator: M. Gnana Sowmya,* K. Jyothi Rama Devi , B. Mounika,K.S.V.L Prasanna,G. Bhavani , A. Venkata Rajesh, D. Aakash
Keywords: 0301 basic medicine, 03 medical and health sciences, 0302 clinical medicine, 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article 14 Apr 2023Publisher:Zenodo

Authors: M. Gnana Sowmya,* K. Jyothi Rama Devi , B. Mounika,K.S.V.L Prasanna,G. Bhavani , A. Venkata Rajesh, D. Aakash;

doi: 10.5281/zenodo.7829718 , 10.5281/zenodo.7829719

FORMULATION AND IN VITRO CHARACTERIZATION OF IBRUTINIB EXTENDED RELEASE TABLETS

- Summary
- Metrics

Abstract

The aim of the present study was to develop extended release formulation of Ibrutinib to maintain constant therapeutic levels of the drug for over 12 hrs. HPMC K100M, HPMC (K4M) and Carbopol 71 G were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e., 98.85% in 12 hours. It contains the HPMC (K4M) as Extended release material. It followed peppas release kinetics mechanism. Keywords: Ibrutinib, Extended release system.

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average