The article presents examination data of patients with hypertension, chronic brain ischemia and Leriche's syndrome. It is noted that in patients with concomitant Leriche's syndrome, the process of dysfunction of the central nervous system is aggravated. The effect of this syndrome on aspects of reduced physical activity, deterioration of cognitive functions (attention and memory), and increased pathological fatigue were reliably revealed. Due to multimorbidity, features of the course of the disease, heterogeneity of pathogenetic mechanisms and risk factors, it is necessary to include patients (men) over 45 years of age in the risk group and, in everyday outpatient practice, be more attentive to complaints of fatigue, weakness when walking, pain symptoms in areas of vascular bifurcation.