Objective: IR is a pathological condition strongly associated with obesity and involved in the pathogenesis of T2D. The treatment of insulin resistant children is firstly targeted to lifestyle interventions. Homeostasis model assessment of insulin resistance (HOMA-IR) may be useful for early evaluation of insulin resistance in children and teenagers and could have a long-term benefit of preventive and diagnostic therapeutic intervention. Method: A cross-sectional study was performed on 80 children and adolescents age 5 to 14 years, 40 of them were apparently healthy with Body mass index (BMI) < 85th percentile 16 were overweight with BMI>85th percentile and below 95th percentile 24 were obese with > 95th percentile. Physical activity was classified on basis of WHO guidelines. Out of 80 children 33 were active and 47 were less active. After overnight fasting for 8 hr, blood samples were taken serum insulin and fasting blood glucose were analysed. Insulin resistance was assessed by homeostasis model of assessment. Result and Conclusion: Our results revealed altered values of HOMA-IR in children with high BMI and mean values were high in children with decrease physical activity. We concluded that more studies should be conducted to focus on preventing and identifying risk factors in children.