The aim of the research was to synthesize formaldehyde phenolic resin (RPF) nanospheres using the aldol condensation method. The Novel of RPF@PdNPs Nanospheres that were prepared at that time was used as a reducing agent and stabilizing supported for the synthesis of PdNPs nanoparticles. It turns out phenol replacement led to a significant decrease in nanosphere size and an increase in the surface roughness of the nanospheres, which ultimately increases the specific surface area of ​​the RPF nanospheres. Because of enhanced specific surface area and excellent reducing activity of RPF (Formaldehyde Phenol Resin), prepared RPF nanospheres have a very high amount of PdNPs loading. Therefore, the as-prepared of RPF@PdNPs nanospheres exhibit a highly efficient catalytic capability for the reduction of Cr(VI) toxicity.