Female infertility is a public health problem by the WHO. Several couples around the world are faced with this problem, a real psychosocial drama. Medical and surgical history, hormonal disorders are its main contributing factors. Currently, several treatment options are possible. Patients and method:- Descriptive cross-sectional study, including 119 patients followed in the gyneco-obstetrics department for the desire of motherhood. It extends over a period of 2 years. Age, marital status, contributing factors, gyneco-obstetrical history, type of infertility, different treatments offered and treatment outcome were our main variables of interest. Results:- The overall frequency of female infertility was 37.5%. Women aged 30 to 34 and married women were the most affected. Ovulatory disorders were the most common etiology with a clear predominance of secondary infertility. Cystectomies and clandestine abortions were among the most found factors. The gynecological ultrasound was the main investigative workup because of the impossibility of performing other examinations. Of all the patients treated, only 23 women had conceived after the treatment. Conclusion:- Infertility is a serious problem for couples in our circles. The university clinics of Uélé are faced with a problem of investigation and its success rate remains low.