Background: The World Health Organization (WHO) recommendation to “test and treat all” HIV-positive Individuals resulted in a 38% fall in new HIV infections and related deaths by 2017. However, the burden of high patient influx in hospitals is reduced by the differentiated model of care to dispense Antiretroviral therapy (ART) from community pharmacies. This study aims to ascertain the level of satisfaction of PLHIV on differentiated care and to evaluate the elements that affect their overall satisfaction. Methods: A cross-sectional descriptive study of One hundred and thirty (130) stable PLHIV ≥18 years who presented at the Rivers State University Teaching Hospital (RSUTH), Port Harcourt, for six- monthly follow up. Ethical approval was obtained from the ethical board of RSUTH (RSUTH/REC/2021052). Structured interviewer-administered questionnaires were used, and associations analysed with statistical significance set at p value of ≤0.05. Results: The Overall satisfaction with services provided by the community pharmacies was 93.85%. Regarding the various elements of satisfaction assessed, 118(90.8%) persons were satisfied with time spent with the community pharmacists, 119 (91.5%) reported being shown courtesy and respect by pharmacist staff, 125 (96.2%) received satisfactory adherence counselling and 126 (96.9%) respondents were satisfied with receiving information on drug therapy. Conclusion: Differentiated model of care in community pharmacies has provided good patient satisfaction, and quality of care in PLHIV in Rivers State.