Bifurcation lesions were once indicating surgery but not anymore, now they will follow the same principles for revascularization of non-bifurcation lesions. However, PCI of bifurcation lesions can be world widely challenging due to anatomic characteristics of each lesion. Guidewire fracture is known to be a rare complication of percutaneous coronary intervention. The consequences however might be deadly, and its management is still debated until further guidelines. The aim of this article is to raise the difficulties of the interventional care of the LAD/Diagonal lesions.