This deliverable concerns to the case study research, focusing on vulnerable populations and on identifying vulnerability and adaptation communalities which increase vulnerability and/or resilience to COVID-19 impacts across several relevant system levels (e.g., governance, public health, community, information), through a multidisciplinary, intersectional & complex systems approach. From a conceptual perspective, this deliverable validates the SES Framework proposed to provide a comparative evaluation of the 101 case studies: FS (Portugal); UANTWERP (Belgium); URJC & SAMUR (Spain); SAPIENZA & UCSC (Italy); SYNYO (Austria); SINUS & UGOT (Germany & Sweden); KEMEA (Greece); SWANSEA (Wales); and MDI (England). All case studies, despite their different objectives, are focused in better understanding the ways the pandemic impacted certain vulnerable communities. In order to do so, secondary (e.g., existing databases) and primary data (e.g., interviews) involving the different systems (national and local) has been collated to provide a baseline overview, at different time points of the pandemic.