Machine Translated by Google UkrNDI OF MEDICINE OF TRANSPORT MOH TERNOPIL STATE MEDICAL UNIVERSITY named after I. Y. HORBACHEVSKY A. I. GOZHENKO M. M. KORDA O. O. POPADYNETS I. L. POPOVYCH ENTROPY, HARMONY, SYNCHRONIZATION AND THEIR NEURO-ENDOCRINE-IMMUNE CORRELATIONS Monograph Odesa Phoenix 2021 Machine Translated by Google UDC 616-003.96: 616-084: 536(075.8) G 57 Recommended for publication by the Academic Council of the State Enterprise Ukrainian Research Institute of Transport Medicine of the Ministry of Health of Ukraine (protocol No. 5 dated June 30, 2021) Reviewers: Ivan Volodymyrovych Savytskyi, doctor of medical sciences, professor, pro-rector for scientific and pedagogical work, head of the department of medical and biological disciplines of Odesa International Medical University Ruslan Serhiyovych Vastyanov, Doctor of Medical Sciences, Professor, Honored Worker of Science and Technology of Ukraine, Head of the Department of General and Clinical Pathological Physiology named after V.V. Pidvysotskyi of Odessa National Medical University G 57 Gozhenko A.I. [etc.]. Entropy, harmony, synchronization and their neuro- endocrine-immune correlates: monograph / A.I. Gozhenko, M. M. Korda, O. O. Popadynets, I. L. Popovych. – Odesa: Phoenix, 2021. – 232 p. DOI https://doi.org/10.5281/zenodo.7764769 ISBN 978-966-928-715-1 The monograph summarizes data from the literature and the results of own research on the relationship of information parameters - entropy, harmony and synchronization - with the parameters of the neuro-endocrine-immune complex of experimental animals and patients of the Truskavets resort. It has been demonstrated that information parameters, primarily entropy, are markers of the integral state of the neuro-endocrine-immune complex, which is responsible for the adaptation of the organism to adverse factors of a physical, chemical, and biological nature. For medical rehabilitation specialists, immunologists, endocrinologists, pathophysiologists. UDC 616-003.96: 616-084: 536(075.8) ISBN 978-966-928-715-1 DOI https://doi.org/10.5281/zenodo.7764769 © A.I. Gozhenko, M. M. Korda, O. O. Popadynets, I. L. Popovych, 2021 © UkrNDI of transport medicine, 2021 © Ternopil State Medical University named after I. Ya. Gorbachevsky, 2021 Machine Translated by Google Content Information about the authors. 4 Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 INTRODUCTION 7 CHAPTER 1. APPLICATION OF ENTROPY DETERMINATION IN MEDICAL RESEARCH. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . SECTION 2. 12 INFORMATIONAL EFFECTS OF BIOACTIVE OIL WATER. . . . 45 CHAPTER 3. RELATIONSHIPS BETWEEN ENTROPYS OF MORPHO-FUNCTIONAL IMMUNE SUBSYSTEMS (THYMUS, SPLEEN, PERIPHERAL BLOOD) AND PARAMETERS OF THE NEURO-ENDOCRINE-IMMUNE COMPLEX IN RATS OF BOTH SEXES. 72 CHAPTER 4. FACTOR ANALYSIS OF THE INFORMATION FIELD OF PARAMETERS OF NERVOUS REGULATORY STRUCTURES (EEG/VRS) AND IMMUNITY. 107 CHAPTER 5. CORRELATION RELATIONS BETWEEN ENTROPY OF NERVOUS REGULATORY STRUCTURES (EEG/VRS) AND PARAMETERS OF IMMUNITY. . CHAPTER 6. INDIVIDUAL CHARACTERISTICS OF ENTROPY PARAMETERS OF NERVOUS REGULATORY STRUCTURES (EEG/VRS). . . . . . . . . . . . . . . . . . . 122 132 CHAPTER 7. CHARACTERISTICS OF AMPLITUDE-FREQUENCY AND SPECTRAL PARAMETERS OF EEG/VRS IN PERSONS WITH DIFFERENT STATE OF ENTROPY. 143 CHAPTER 8. FEATURES OF THE NEURO-IMMUNE COMPLEX IN PERSONS WITH DIFFERENT STATE OF ENTROPY OF NERVOUS REGULATORY STRUCTURES. . 157 CHAPTER 9. OPTIONS OF CHANGES IN EEG, HRV, LCG AND ICG ENTROPY UNDER THE INFLUENCE OF ADAPTOGENEIC BALNEOTHERAPY AND THEIR PREDICTIONS. 169 CHAPTER 10. IMMUNE SUPPORT OF POLYVARIANT REACTIONS OF ENTROPY TO ADAPTOGENIC BALNEOTHERAPY. CHAPTER 11. 188 RELATIONSHIPS BETWEEN THE ENTROPY OF THE PARAMETERS OF THE NEURO-IMMUNE COMPLEX AND GAS DISCHARGE VISUALIZATION. 207 CONCLUSION. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Literature . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 213 215 3 Machine Translated by Google Information about the authors Anatoly Ivanovich Gozhenko, Doctor of Medical Sciences, Professor, Honored Worker of Science and Technology of Ukraine, Director of the State Enterprise "Ukrainian Research Institute of Transport Medicine of the Ministry of Health of Ukraine", President of the Scientific Society of Pathophysiologists of Ukraine, Chairman of the Public Organization "Ukrainian Association of Medical Science". Author of more than 1,650 scientific works (more than 95 publications in scientific journals indexed in the Web of Science Core Collection and Scopus), including 67 monographs, 82 author's certificates and patents, 8 textbooks, 4 training manuals, 2 methodological manuals. A. I. Gozhenko created the international scientific school "Pathophysiology of water- salt exchange and kidney function". Under his scientific guidance and counseling, 30 doctors and 72 candidates of sciences were trained. Mykhailo Mykhailovych Korda, Doctor of Medical Sciences, Member-Cor of the National Academy of Sciences of Ukraine, Honored Worker of Science and Technology of Ukraine, Professor of the Department of Medical Biochemistry, Rector of Ternopil National Medical University named after I. Ya. Gorbachevsky. Field of scientific interests: biochemistry of free radicals; hepatotoxicology; the role of nitric oxide in the pathology of the cardiovascular system; endothelial dysfunction mechanisms in obesity, hypertension, atherosclerosis, COVID-19; nanotoxicology, application of nanomaterials in medicine and pharmacy; epidemiology, pathogenesis, treatment of borrelio Korda M. M. is the author of 455 scientific works, including 11 monographs, 4 textbooks Kiev, 9 teaching and methodical manuals. M. Korda is the chief editor of the scientific journals "Medical and Clinical Chemistry", "International Journal of Medicine and Medical Research, a member of the editorial boards of 3 foreign journals. Ihor Lvovych Popovych is a famous Ukrainian scientist in the field of balneology and physiology. Employee (1983–2009) and head (2010–2016) of the laboratory of experimental balneology of the Institute of Physiology named after O.O. Bogomolets National Academy of Sciences of Ukraine. Scientific (2003–2011) and chief (2012–2013) editor of the journal "Medical Hydrology and Rehabilitation". Chairman of the Council of the Truskavets Association of Scientists (since 1999). Honors: Prize named after O.O. Bogomolets of the National Academy of Sciences of Ukraine in the field of physiology (1998), Prize named after Teodor Torosevich of Truskavetskurort CJSC in the field of balneology (2000), Certificate of Honor of the Presidium of the National Academy of Sciences of Ukraine (2004), medal "25 years of independence of Ukraine" Oleksandr Oleksiyovych Popadynets - vice-rector for infrastructure development of the Southern Ukrainian National Pedagogical University named after K.D. Ushin of He has more than 40 years of practical work experience in clinical medical and preventive institutions of Ukraine (CLPU) in the specialty "Physician", of which more than 30 years he was engaged in the organization of medical assistance to the population, and the development of the activities of medical universities in the positions of chief physician and vice-rector. The author of more than 30 scientific works devoted to the study of various problems of medicine. He has more than 10 years of teaching experience. 4 Machine Translated by Google Preface The development of civilization is based on continuous human knowledge (mankind) of the world. The main objects of knowledge are the person himself and the environment environment. At the same time, the basic logic of this process has developed and exists: from general ideas to an analytical approach that develops and deepens them, that and allows further formation of an objective picture of the world. Medical science also has a general logico-historical approach to understanding the essence of a person. Indeed, the primary idea of the human body as a holistic phenomenon of nature gradually moved to the analytical study of its essence from its structure, i.e. morphology, to the function of individual components and finally to their chemical (biochemical) nature. Despite the huge amount of material collected by medicine, we see many questions that need to be answered understanding as the essence of a biochemical component and especially a physical basis life. But the more data accumulates about the human body and our knowledge about the structure and function of its individual parts deepens components, the more we move away from understanding the human body as holistic phenomenon, its main characteristics, which are health and life in as a whole Although they are the main subject of medicine. Such a dialectic holistic and its structure, and therefore the accumulation of knowledge on elementary components logically requires understanding and characteristics of whole objects nature Taking into account that every object of nature exists due to the fact that it is a system, the concept of the main general characteristic of any system, its entropy, which characterizes the general energy principle of existence - a constant direction to decrease the energy level, i.e. essentially destruction, was formed in science of this system. It goes without saying that biological organisms are the most complex systems that have evolved in nature, and man is the most complex, i.e. super system That is why the human body is relatively stable over time thanks to metabolism, which ensures this temporary state, that is, life. 5 Machine Translated by Google Medicine itself aims to ensure the maximum stability of human existence in the environment. Moreover, the main indicators of a person's existence are his health and life expectancy, which are the subject of the scientific and practical activity of medicine, which, in order to achieve this goal, studies individual morpho-functional indicators that allow us to understand the state of the body and influence him. At the same time, studying (diagnosing) all these valuable components of the body of man, we are moving more and more away from the general characteristics of the self of a complex supersystem, but instead from ideas about its stability. On our view, continuing the development of an analytical approach to the human body there comes a time when it becomes necessary to define general characteristics organism, namely its entropy as an indicator of the energy state, and instead the ability to ensure relative stability of existence. However, in modern medicine there are only separate attempts to characterize it organism according to its entropy indicators in connection with the existing priorities determination of specific changes. However, in the case when physiological loads on the human body is not significant or the pathological changes are also not large, it is rather difficult to characterize its condition. Exactly in these cases the entropy indicator can give an idea of the general state of the organism. In this regard, the authors set the goal of determining the entropy changes of the main systems that ensure the functional stability of the body in the conditions of sanatorium-resort treatment, because in these cases, pathological changes, as a rule, are not significant, and the operating factors also do not cause significant differences 6 Machine Translated by Google INTRODUCTION Despite the fact that information medicine, like homeopathy and biophotonics, still did not receive academic status (and not so long ago this was the case acupuncture and more recently - theoneurology), it has an ancient background. If we translate the first lines of the Gospel of John from religious language to scientific language (logos = word = information; God = World Mind = information space of the Universe), we will get: "The first was Information, and the World Mind had Information , and the World Mind was Information. It was primary in the World Mind ... Everything arose through Information ... Information became a body." By the way, here is the answer to the main question of philosophy regarding the primacy of the ideal or the material. In a general sense, bioinformation is a message about events from external and internal environment, perceived stimuli biosystems and affect life processes. Biloshitsky PV and others. [2005] suggest that the very appearance of life on our planet is a result