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</script>Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes. The present investigation is concerned with the development of the metformin HCl buccal films, which were designed to prolong the buccal residence time, to increase penetration through buccal mucosa and thus increase the bioavailability and its half-life. Various formulations were developed by using release rate controlling film forming polymers like HPMC 5cps and HPMC 50cps in various combinations using plasticizer PEG 400. The prepared films were evaluated for number of parameters like physical appearance and surface texture, weight uniformity, thickness of the films, folding endurance, swelling index, tensile strength, drug excipients interaction study, content uniformity, in-vitro drug release study. The FTIR studies indicate that Metformin HCl showed complete entrapment within the polymer carrier bonding is suggested and there was no chemical interaction. From all the formulations, F8 shows maximum drug release at the ends of 8 hr and chosen as optimized formulation and which follows zero order release with super case II transport mechanism. Keywords: Metformin HCl, HPMC, FTIR, super case II transport
| citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 0 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average | 
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