Abstract A 48-year-old male was diagnosed with a rare head and neck tumor of solitary extramedullary plasmacytoma. Limited literature exists on the management of extramedullary plasmacytoma. Radiation therapy remain to be the mainstay treatment but surgery can be utilized for symptomatic relief, increasing radiation effectiveness, and in cases of neurologic instability. Due to lack of consensus guidelines for its management, a multidisciplinary team conference was held to discuss the management for the patient. The patient underwent endoscopic tumor debulking with medial maxillectomy, followed by postoperative radiation. Post-treatment, the patient had post-radiation symptoms such as decreased vision and hearing but with gross disease improvement and improved obstructive symptoms. Magnetic resonance imaging done one month after treatment showed no residual disease.