Abstract: The effect of ethanol extract of Chromolaena odorata on reproductive hormones and histology of the testes in adult male albino rats was investigated in this study. Twenty male albino rats weighing between 120-130g were used for this study. They were randomly divided into four (4) groups, n=5. Group 1 served as control group and administered with distilled water only. Groups 2, 3, and 4 were orally administered with 250mg/kg, 500mg/kg and 100mg/kg body weight (b.w) of the extract respectively. At the end of experimental period of 14 days, the animals were fasted overnight and sacrificed by cervical dislocation. Testis tissues and blood samples were collected and taken to the laboratory for biochemical analysis using standard procedures. The result showed that 250mg/kg b.w of Chromolaena odorata administered to group 2 rats had no significant difference (p>0.05) in Luteinizing hormone (LH), follicle stimulating hormone ( FSH) , prolactin and testosterone serum concentration when compared to the control group while groups administered with 500mg/kg and 1000 mg/kg b.w of Chromolaena odorata extract respectively, had significant (p<0.05) decrease in concentration of LH, FSH, testosterone and a significant increase in serum prolactin concentration. There was normal testicular architecture in groups 2 and 3 administered with 250mg/kg and 500mg/kg b.w. However, testicular atrophy was observed in group 4 administered with 1000mg/kg b.w. from the histology of the testes. From this study, it can be deduced that the extract exhibited potential to induce spermatogenic arrest in male albino rats. Keywords: Reproductive hormones, Testes, Histology, Graded Doses and Chromolaena odorata. Title: REPRODUCTIVE HORMONE CHANGES IN MALE WISTAR RATS ADMINISTERED GRADED DOSES OF Chromolaena odorata LEAF EXTRACT Author: Okwakpam, FN, Omeodu SI, Odinga, T, Ijeoma, SN International Journal of Recent Research in Life Sciences (IJRRLS) ISSN 2349-7823 Vol. 10, Issue 1, January 2023 - March 2023 Page No: 33-40 Paper Publications Website: www.paperpublications.org Published Date: 06-March-2023 DOI: https://doi.org/10.5281/zenodo.7701708 Paper Download Link (Source) https://www.paperpublications.org/upload/book/REPRODUCTIVE%20HORMONE%20CHANGES-03062023-5.pdf

International Journal of Recent Research in Life Sciences (IJRRLS), ISSN 2349-7823, Paper Publications, Website: www.paperpublications.org