{"references": ["Ali AM. 2018. 'Detection of PPCPs in marine organisms from contaminated coastal waters of the Saudi Red Sea', Science of the Total Environment. Elsevier B.V 621, pp. 654-662. doi: 10.1016/j. scitotenv.2017.11.298.", "Anderson C, Destouni G. 2001. 'Risk\u2010Cost Analysis in Ground Water Contaminant Transport: The Role of Random Spatial Variability and Sorption Kinetics', Ground water 39(1), pp. 35-48.", "Armstrong DL. 2018. Degradation of triclosan and triclocarban and formation of transformation products in activated sludge using benchtop bioreactors, Environmental Research. DOI: 10.1016/ j.envres. 2017.10.048.", "Awad AH. 2018. 'Air microbial quality in certain public buildings, Egypt: A comparative study', Atmospheric Pollution Research. Elsevier B.V 9(4), pp. 617-626. doi: 10.1016/j.apr.2017.12.014.", "Badi I, Shetwan A, Hemeda A. 2019. 'A grey-based assessment model to evaluate health-care waste treatment alternatives in Libya', Operational Research in Engineering Sciences: Theory and Applications 2(3), pp. 92-106. doi: 10.31181/ oresta1903092b.", "Boberg J. 2019. 'A pragmatic approach for human risk assessment of chemical mixtures', Current Opinion in Toxicology. Elsevier B.V 15, pp. 1-7. DOI: 10.1016/j.cotox.2018.11.004.", "Choudhury AR, Veeraraghavan A. 2018. 'Treatment of Highly Concentrated Effluent Generated from Intermediate Chemical and Bulk Drug Industries Renovated with Tertiary Removal', (December) pp. 1-5. DOI: 10.19080/IJESNR. 2018.12.555831.", "Cordaillat-Simmons M, Rouanet A, Pot B. 2020. 'Live biotherapeutic products: the importance of a defined regulatory framework', Experimental and Molecular Medicine. Springer US 52(9), pp. 1397-1406. DOI: 10.1038/s12276-020-0437-6.", "Felis E. 2020. 'Antimicrobial pharmaceuticals in the aquatic environment \u2013 occurrence and environmental implications', European Journal of Pharmacology. Elsevier BV 866, p. 172813. DOI: 10.1016/j.ejphar. 2019.172813.", "Finkel AM, Gray GM. 2021. 'The Pebble Remains in the Master's Hand: Two Careers Spent Learning (Still) from John Evans', Risk Analysis 41(4), pp. 678-693. DOI: 10.1111/risa.13649.", "Fragkaki AG. 2013. 'Sports doping: Emerging designer and therapeutic \u03b22-agonists', Clinica Chimica Acta, pp. 242-258. DOI: 10.1016/j.cca. 2013.07.031.", "Furlong ET. 2017. 'Nationwide reconnaissance of contaminants of emerging concern in source and treated drinking waters of the United States: Pharmaceuticals', Science of the Total Environment. Elsevier B.V 579, pp. 1629-1642. DOI: 10.1016/ j.scitotenv.2016.03.128.", "Van Genuchten MT. 2013. 'Exact analytical solutions for contaminant transport in rivers 1. The equilibrium advection-dispersion equation', Journal of Hydrology and Hydromechanics 61(2), pp. 146-160. DOI: 10.2478/johh-2013-0020.", "Gilcreas FW. 1967. Future of standard methods for the examination of water and wastewater., Health laboratory science.", "Grenni P. 2019. 'Sulfamethoxazole persistence in a river water ecosystem and its effects on the natural microbial community and Lemna minor plant', Microchemical Journal. Elsevier 149, p. 103999. DOI: 10.1016/j.microc.2019.103999.", "Gunnarsson, Lina Snape, Jason R, Verbruggen, Bas Owen, Stewart F Kristiansson, Erik Margiotta-Casaluci, Luigi \u00d6sterlund, Tobias Hutchinson, Kathryn Leverett, Dean Marks, Becky Tyler CR. 2019. 'Pharmacology beyond the patient \u2013 The environmental risks of human drugs', Environment International. Elsevier 129, pp. 320-332.", "Gunnarsson, Lina Snape, Jason R Verbruggen, Bas Owen, Stewart F, Kristiansson E, Margiotta-Casaluci, Luigi \u00d6sterlund T, Hutchinson, Kathryn Leverett, Dean Marks, Becky Tyler CR. 2019. 'Pharmacology beyond the patient \u2013 The environmental risks of human drugs', Environment International. Elsevier 129(April) pp. 320-332. DOI: 10.1016/j.envint.2019.04.075.", "Han B. 2017. 'Prescription opioid use, misuse, and use disorders in U.S. Adults: 2015 national survey on drug use and health', Annals of Internal Medicine 167(5), pp. 293-301. DOI: 10.7326/M17-0865.", "Hasan S. 2018. 'Changing Nature of Waste\u202f: Pharmaceuticals and Personal Care Products Changing Nature of Waste\u202f: Pharmaceuticals and Personal Care Products' (August), pp. 1-9.", "Hossein M. 2018. 'Spatial Occurrence and Fate Assessment of Potential Emerging Contaminants in the Flowing Surface Waters', Chemical Science International Journal 24(2), pp. 1-11.", "Jaiswal DK, Kumar A, Yadav RR. 2011. 'Analytical Solution to the One-Dimensional Advection-Diffusion Equation with Temporally Dependent Coefficients', Journal of Water Resource and Protection 03(01), pp. 76-84.", "Jeong Y. 2020. 'Accumulation and time trends (2003-2015) of persistent organic pollutants (POPs) in blubber of finless porpoises (Neophocaena asiaeorientalis) from Korean coastal waters', Journal of Hazardous Materials. Elsevier BV 385(2020), p. 121598. DOI: 10.1016/j.jhazmat.2019.121598.", "Khan HK, Rehman MYA, Malik RN. 2020. 'Fate and toxicity of pharmaceuticals in water environment: An insight on their occurrence in South Asia', Journal of Environmental Management. Elsevier Ltd 271, p. 111030. DOI: 10.1016/ j.jenvman.2020.111030.", "Li Yan Zhang, Luyan Liu, Xianshu Ding J. 2019. 'Ranking and prioritizing pharmaceuticals in the aquatic environment of China', Science of the Total Environment. Elsevier BV 658, pp. 333-342. DOI: 10.1016/j.scitotenv.2018.12.048.", "Li Y. 2019. Insight into the distribution of pharmaceuticals in soil-water-plant systems, Water Research. DOI: 10.1016/j.watres.2018.12.039.", "Lv Y. 2020. 'Sources, concentrations, and transport models of ultrafine particles near highways: a Literature Review', Building and Environment. Elsevier Ltd 186, p. 107325.", "Madikizela LM, Tavengwa NT, Chimuka L. 2017. 'Status of pharmaceuticals in African water bodies: Occurrence, removal and analytical methods', Journal of Environmental Management. Elsevier Ltd 193, pp. 211-220.", "Makokola SK, Asha Ripanda, Hosein Miraji. 2020. 'Quantitative Investigation of Potential Contaminants of Emerging Concern in Dodoma City: A Focus at Swaswa Wastewater Stabilization Ponds', Egyptian Journal of Chemistry, 63(Special Issue (Part 2) Innovation in Chemistry, April 2020), pp. 5-6.", "Marti E, Variatza E, Balcazar JL. 2014. 'The role of aquatic ecosystems as reservoirs of antibiotic resistance', Trends in Microbiology. Elsevier Ltd 22(1), pp. 36-41. DOI: 10.1016/j.tim.2013.11.001.", "Mir-Tutusaus JA, Sarr\u00e0 M. 2020. 'Fungal Reactors: A Solution for the Removal of Pharmaceuticals in Urban and Hospital Wastewater', in The Handbook of Environmental Chemistry. Berlin Heidelberg: Springer Berlin Heidelberg pp. 1-18. DOI: 10.1007/698_2020_660.", "Miraji H. 2016. 'Research Trends in Emerging Contaminants on the Aquatic Environments of Tanzania', Scientifica, 2016. DOI: 10.1155/2016 /3769690.", "Munschy C. 2020. 'Legacy and emerging organic contaminants: Levels and profiles in top predator fish from the western Indian Ocean in relation to their trophic ecology', Environmental Research. Elsevier Inc 188, p. 109761. DOI: 10.1016/j.envres. 2020. 761.", "Nantaba F. 2020. 'Occurrence, distribution, and ecotoxicological risk assessment of selected pharmaceutical compounds in water from Lake Victoria, Uganda', Chemosphere. Elsevier Ltd 239, p. 124642. DOI: 10.1016/j.chemosphere.2019.124642."]}

Researchers repeatedly discovered primary pharmaceutical contaminants, their metabolites, and transformation products in aquatic ecosystems. Body metabolism may not convert consumed pharmaceuticals to their metabolic elements before excretion. In this case, clinical and industrial wastes ensure their presence in the environment. Nevertheless, conventional wastewater treatment methods are ineffective for removing pharmaceutical wastes. Once in the ecosystem, they alter the physiological response of nontarget exposed aquatic and even terrestrial organisms due to induced toxicity. In the course of this study at Swaswa Wastewater Stabilization Ponds (SWSP), the transport of the quantified 0.104 ppm of metronidazole under advection mode in a laminar flow to a longitudinal predictive distance of 230 m. Beyond this distance, no significant concentration changes. The quantified metronidazole had a risk quotient of less than 1, implying no toxicity risks. Despite being acceptable, their hydrophobic nature and physiological activeness present a long-term ecological risk such as developing antibiotic resistance genes, endocrine disruption, and immunity suppression. A combination of engineered constructed wetlands and adsorption using biodegradable adsorbents are among natural remedial practices for eliminating pharmaceuticals with promising efficacy, cost-effectiveness and being environmentally friendly. Published by the Journal of Biodiversity and Environmental Sciences | JBES