Five pilot studies will be carried out as part of iHelp, to help test and validate the solution developed in the project. These pilots’ studies that will be further detailed in D6.1 (“Coordination of pilot scenarios for personalised healthcare – early risk identification, prevention and intervention measures I”) and in D6.2 (“Coordination of pilot scenarios for personalised healthcare – early risk identification, prevention and intervention measures II”) should be set up and implemented by healthcare partners in close collaboration with technical partners. This series of deliverables, i.e., D6.3 (“Pilot setup and implementation of digital trials I”) and D6.4 (“Pilot setup and implementation of digital trials II”), contributes to the description of the set up and implementation process, the former assessing the requisites and milestones to allow the pilots start and the latter assessing the work performed after the end of the pilots (also referred as digital trials). In. addition, it describes if the objectives have been reached. The overall objective of this document is to contain the description of the set-up process for each pilot, and its level of development by M18 of the project, allowing to foresee deviations and potential risks that may jeopardize the pilots start, that is expected around M21 of the project.