Enteric fever caused by Salmonella enterica continues to be a major public health problem worldwide. In the last decade, ceftriaxone and ciprofloxacin have become the drugs of choice for treating enteric fever caused bySalmonella enteric serovar typhi. A retrospective study to understand the prevalence and evolving the minimum inhibitory concentration trends of ceftriaxone and ciprofloxacin . A total of 100 blood samples were collected from patients attending inpatient and outpatient departments of of pediatric patients suffering from typhoid fever at MSSH, Delhi from May 2012 to December 2013.Since enteric fever is endemic in India, accurate drug susceptibility surveillance is crucial to ensure empiric management of enteric fever is appropriate. This retrospective study aimed to evaluate the minimum inhibitory concentration trends of ceftriaxone and ciprofloxacin in blood culture of pediatric patients suffering from Typhid fever in Max Super Specialty Hospital, New Delhi, India Keywords-Typhoid fever, ciprofloxacin, pediatric patients, retrospective study.