References: 1. Simpson NB, Cunliffe WJ. Disorders of the sebaceous glands. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook's Text book of Dermatology. 7th ed. Vol. 43. Blackwell Science; 2004. pp. 43.1–43.75. 2. Gollnick HP, Zouboulis CC, Akamatsu H, Kurokawa I, Schulte A. Pathogenesis and pathognesis-related treatment of acne. J Dermatol. 1991;18:489–99. 3. Leyden JJ. New understanding of the pathogenesis of acne. J Am Acad Dermatol. 1995;32:515–25. 4. Plewig G, Kligman AM. Acne and Rosacea. 3rd ed. New York: Springer-Verlag; 2000.] 5. Cunliffe WJ, Gollnick HP. Acne: Diagnosis and management. 1st ed. London: Martin Dunitz Ltd; 2001. 6. Packman AM, Brown RH, Dunlap FE, Kraus SJ, Webster GF. Treatment of acne vulgaris: Combination of 3% erythromycin and 5% benzoyl peroxide in a gel compared to clindamycin phosphate lotion. Int J Dermatol. 1996;35:209–11. 7. Yang DJ, Quan LT, Hsu S. Topical antibacterial agents. In: Wolverton SE, editor. comprehensive dermatologic drug therapy. 2nd ed. Philadelphia: Saunders Elsevier; 2007. pp. 525–46. 8. Fyrand O, Jakobsen HB. Water-based versus alcohol-based benzoyl peroxide preparations in the treatment of acne vulgaris. Dermatologica. 1986;172:263–7. 9. Mills OH, Jr, Kligman AM, Pochi P, Comite H. Comparing 2.5%, 5% and 10% benzoyl peroxide on inflammatory acne vulgaris. Int J Dermatol. 1986;25:664–7. 10. Bojor RA, Cunliffe WJ, Holland KT. The short term treatment of acne vulgaris with benzoyl peroxide: Effects on the surface and follicular cutaneous microflora. Br J Dermatol. 1995;132:204–8. 11. Eady EA, Cove JH, Joanes DN, Cunliffe WJ. Topical antibiotics for the treatment of acne vulgaris: A critical evaluation of the literature on their clinical benefit and comparative efficacy. J Dermatol Treat. 1990;1:215–26. 12. Krishnan G. Comparison of two concentrations of tretinoin solution in the topical treatment of acne vulgaris. Practitioner. 1976;216:106–9. 13. Shalita A, Weiss JS, Chalker DK, Ellis CN, Greenspan A, Katz HI, et al. A comparison of the efficacy and safety of adapalene gel 0.1% and tretinoin gel 0.025% in the treatment of acne vulgaris: A multicentric trial. J Am Acad Dermatol. 1996;34:482–5.] 14. Leyden JJ, Shalita A, Thiboutot D, Washenik K, Webster G. Topical tretinoin in inflammatory acne: A retrospective, investigator-blinded, vehicle-controlled, photographic assessment. Clin Ther. 2005;27:216–24.

Abstract In recent years, with a better understanding of the pathogenesis of acne, new treatments have been developed. The availability of new treatment options that complement the existing protocol should help to successfully treat more patients with acne, ensure better tolerability and meet patient expectations. Successful treatment of acne requires careful selection of anti-acne products in accordance with the clinical picture and the individual needs of the patient.