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Fundamentals of SARS CoV-2 Proteome and Variants

Authors: Nirjar Bhattacharya;

Fundamentals of SARS CoV-2 Proteome and Variants

Abstract

{"references": ["Benedetti, F., Snyder, G. A., Giovanetti, M., Angeletti, S., Gallo, R. C., Ciccozzi, M., Zella, D. (2020, August 31). Emerging of a SARS-COV-2 viral strain with a deletion in NSP1. Journal of Translational Medicine. https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02507-5.", "Duan, L., Zheng, Q., Zhang, H., Niu, Y., Lou, Y., Wang, H. (1AD, January 1). The sars-COV-2 spike glycoprotein biosynthesis, structure, function, and antigenicity: Implications for the design of spike-based vaccine immunogens. Frontiers. https://www.frontiersin.org/articles/10.3389/fimmu.2020.576622/full.", "Huang, Y., Yang, C., Xu, X.-feng, Xu, W., Liu, S.W. (2020, August 3). Structural and functional properties of SARS-COV-2 spike protein: Potential antivirus drug development for covid-19. Nature News. https://www.nature.com/articles/s41401-020-0485-4.", "Khateeb, J., Li, Y., Zhang, H. (2021, July 12). Emerging sars-COV-2 variants of concern and potential intervention approaches. Critical Care. https://ccforum.biomedcentral.com/articles/10.1186/s13054-021-03662-x.", "Mittal, A., Manjunath, K., Ranjan, R. K., Kaushik, S., Kumar, S., Verma, V. (n.d.). Covid-19 pandemic: Insights into structure, function, and hACE2 receptor recognition by SARS-COV-2. PLOS Pathogens. https://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1008762.", "Pachetti, M., Marini, B., Benedetti, F., Giudici, F., Mauro, E., Storici, P., Masciovecchio, C., Angeletti, S., Ciccozzi, M., Gallo, R. C., Zella, D., Ippodrino, R. (2020, April 22). Emerging sars-COV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. Journal of Translational Medicine. https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02344-6.", "Rashid, F., Suleman, M., Shah, A., Dzakah, E. E., Wang, H., Chen, S., Tang, S. (1AD, January 1). Mutations in SARS-COV-2 ORF8 altered the bonding network with interferon regulatory factor 3 to evade host immune system. Frontiers. https://www.frontiersin.org/articles/10.3389/fmicb.2021.703145/full.", "Redondo, N., Zald\u00edvar-L\u00f3pez, S., Garrido, J. J., Montoya, M. (1AD, January 1). SARS-COV-2 accessory proteins in viral pathogenesis: Knowns and unknowns. Frontiers. https://www.frontiersin.org/articles/10.3389/fimmu.2021.708264/full.", "Schoeman, D., Fielding, B. C. (2019, May 27). Coronavirus envelope protein: Current knowledge. Virology journal. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537279/.", "V'kovski, P., Kratzel, A., Steiner, S., Stalder, H., Thiel, V. (2020, October 28). Coronavirus Biology and replication: Implications for SARS-COV-2. Nature News. https://www.nature.com/articles/s41579-020-00468-6.", "Zhang, K., Miorin, L., Makio, T., Dehghan, I., Gao, S., Xie, Y., Zhong, H., Esparza, M., Kehrer, T., Kumar, A., Hobman, T.C., Ptak, C., Gao, B., Minna, J.D., Chen, Z., Garc\u00eda-Sastre, A., Ren, Y., Wozniak, R.W., Fontoura, B.M.A. (n.d.). NSP1 protein of SARS-COV-2 disrupts the mrna export machinery to inhibit host gene expression. Science advances. https://pubmed.ncbi.nlm.nih.gov/33547084/."]}

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that is responsible for the COVID-19 pandemic. The currently ongoing COVID-19 pandemic has had devastating effects on human health, resulting in 219 million recorded cases and 4.55 million deaths worldwide. Beyond its direct impact on healthcare, this pandemic has also disrupted the daily lives of millions and will likely continue to do alter lifestyles for years through its negative impact on the economy. This paper aims to simplify the SARS-CoV-2 virus so that anybody can understand its molecular function. This paper also explains how this virus is changing with time and how these changes may affect the world’s response to this virus. The information regarding SARS-CoV-2 and its structure is important since knowing this information allows people around the world to learn about this seemingly indomitable virus, to understand how the virus works, and how these variations each have a different impact on their body. All this information will increase the overall public knowledge of the virus and help them avoid misinformation and possible threats from SARS-CoV-2.

Keywords

SARS-CoV-2, biology, viruses, mutations, proteins

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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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