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The primary purpose of this study was to find out whether total quality management and innovation significantly predict the determinants of survival among MSMEs. It was tested at a 0.05 level of significance stating there is no significant relationship between total quality management and innovation on the determinants of survival of MSMEs. The findings revealed that total quality management and innovation of MSMEs were both high. The results show a significant relationship between total quality management and innovation on the determinants of survival among MSMEs. There is no domain in total quality management and innovation that significantly predict the determinants of survival among MSMEs. Furthermore, a significant influence on the determinants of survival was found in the domains of total quality management and innovation