Introduction:Isolated oculomotor nerve palsy (ONP) is quite common in general practice. Various causes of ONP have been described in several studies, for instance ischemia, compression from aneurysm or tumor, and trauma. Ischemia was the most common etiology with spontaneous recovery, and it was presumed based on some helpful clinical clues before imaging became available. Materials & Methods:This study comprises of 10 patients with oculomotor nerve palsy who attended regional eye hospital, Kurnool, during my study period of 6 months from 01/02/2022 to 31/07/2022. Patients presented to OPD with complaints of diplopia and drooping of upper eyelid. Patients subjected to VA for distant and near vision, slit-lamp examination, pupillary reactions, extraocular motility, fundus examination, diplopia charting for distant and near vision, hess charting, visual field testing and IOP. Blood pressure, blood sugar profile, lipid profiles were monitored and referred to concerned departments. They were advised for CT and MRI scans to know the etiological cause. Results:Out of 10 patients, DM - 3, CVA due to Hypertension - 1, ocular tuberculosis - 1, mucormycosis - 1, pseudotumor - 1, trauma - 1, unknown etiology - 2. Conclusion: Patients with diabetes has a good recovery rate. We recommend that the patients with oculomotor nerve palsy be carefully examined clinically in a multidisciplinary approach for early diagnosis and treatment.