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Prin articolul de faţă, ne propunem să abordăm sănătatea mintală şi calitatea vieţii în legătură cu problematica durerii cronice. Astfel, prezentăm o sinteză a literaturii de specialitate explicând iniţial la ce se referă durerea cronică, continuând apoi cu explicarea variabilelor sănătate mintală şi calitate a vieţii, dar şi evidenţierea legăturilor dintre acestea şi durerea cronică, în conformitate cu cercetările din domeniu. De asemenea, propunem o serie de modalităţi prin care să putem gestiona durerea cronică, cu menţiunea că acestea nu sunt prezentate drept absolute şi incontestabile.