Sickle cell disease (SCD) is a hereditary illness characterized by hemolytic anemia, end-organ damage, diminished survival, and discomfort. A literature search was conducted using PubMed, CINAHL, and Embase. Databases were searched for all relevant studies to our topic published up to the beginning of 2022. Recurrent and unpredictable episodes of intense pain due to vasoocclusive crisis requiring hospitalization are one of the distinctive characteristics of SCD. In addition, SCD patients frequently have chronic persistent pain. Presently, opioids are used to treat sickle cell anguish, a method that is limited by unwanted effects. Because pain can begin in infancy and persist throughout life, preventing its onset may be preferable to treating it once it has been triggered.