The medicine launch from Liposomes depends upon many aspects consisting of the structure of Liposomes, the kind of medicine encapsulated and nature of the cell. Once it is released a medicine that generally goes across the membrane of a cell will certainly enter the cell, various other medicines will not go into. Decitabine is a short biological half-life. This research study targeted at Formula As well as In-Vitro Assessment Of Liposomal Drug Shipment System Of Decitabine in order to boost its bioavailability. In examination study the result of the differing make-up of lipids on the residential or commercial properties such as encapsulation efficiency, fragment size as well as medication release were researched. Stage change research was executed to validate the total interaction of Decitabine with bilayer structure of liposome. Moreover, the launch of the drug was likewise modified as well as crossed a duration of 8 h in all solutions. F1 became one of the most acceptable formula in so far as its residential or commercial properties were concerned. Additionally, release of the medicine from the most sufficient formula (F1) was assessed via dialysis membrane layer to get the idea of medication launch. Keywords: Liposomes, Decitabine, Bioavailability.