ABSTRACT Steven Johnson syndrome is a severe and potentially lethal disease due to an immune-complex-mediated hypersensitivity reaction involving mucous membranes and skin. Steven Johnson syndrome and toxic epidermal necrolysis (TEN) are life-threatening diseases characterized by the detachment of skin and mucous membranes. It has been a common belief that herbal drugs do not cause such as much as side effects and toxicities as pure chemicals. Recently, SJS associated with herbal medicine has been reported. This paper aims to report a case of SJS marked with skin manifestations following the use of herbal drugs for the treatment of Alcohol withdrawal and Jaundice. A 28 years male old patient was admitted with complaints of Fever, Vomiting, and Rashes over the body. The patient had received herbal drugs for the treatment of Jaundice and Alcohol dependence. Herbal medicine still plays an important role in the Indian Healthcare system as it is one of the most ancient treatment systems in the Indian Healthcare system. Further studies may require to evaluate the characteristics of the general population and to identify any predisposing factors to SJS as recommended. Keywords: Steven Johnson syndrome, Herbal drugs, Drug-induced reaction, Rashes, Skin lesion, Case report, adverse drug reaction, treatment, SJS, TEN.