Next generation sequencing is a high throughput sequencingtechnology that can be used for diagnostic purposes. This review discusses the use of next generation sequencing technology for the detection and analysis of SARS-CoV-2. There are different parameters to be considered while comparing next generation sequencing technology to more traditional methods of testing. The review also includes the various mutations and evolutions undergone by the virus across the population during the pandemic. This review addresses the methodology, analysis and processing of next generation sequencing in the analysis of SARS-CoV-2 along with other relevant aspects.