Dr Mahapatra Tova Chishi, Dr Devajit Choudhury* Department of General Surgery, Gauhati Medical College and Hospital, Guwahati, Assam, India ABSTRACT: Introduction: Benign disease was responsible for the majority of cases of GOO in adults until the late 1970s, of which peptic ulcer disease accounted for up to 90 percent of cases. With the decline in peptic ulcer disease, it is estimated that 50 to 80 percent of all cases of GOO are attributable to malignancy. Materials and Methods: During the period of study from 1st June 2021 to 31st May 2022, 52 patients with diagnosis of gastric outlet obstruction admitted in Department of Surgery, GMCH were taken up for the purpose of the study. Appropriate haematological and radiological investigations were done as required. Final diagnosis of gastric outlet obstruction has been confirmed on basis of biopsy reports. Results and Observations: A total of 52 cases of adults presenting with gastric outlet presentation was studied. Malignancy was seen in 30 patients, of which 23 patients had carcinoma stomach (44.2%), 4 patients had carcinoma pancreas (7.7%) and 3 had carcinoma gall bladder (5.8%). Peptic ulcer disease was seen in 20 cases (38.5%) and 2 patients (3.8%) had corrosive injury. The age ranged from 24 years to 77 years. Maximum patients belonged to the 7th decade of life. Average age of presentation in malignant group is 54.3 years while in the non-malignant group is 48.4 years. Overall average age of presentation was 51.8 years. Conclusion: Males are more commonly affected with gastric outlet obstructions in adults. Malignancy is more common in the age group of 60-69 years, while cicatrized duodenal ulcer is more common in the age group of 50-59 years. Malignancy is more common as compared to benign diseases causing complication like gastric outlet obstruction. Patients with gastric outlet obstruction due to cicatrized duodenal ulcer require a posterior gastrojejunostomy with or without truncal vagotomy. Malignancy cases require curative or palliative surgery depending on the stage of the disease. Key words: Gastric Outlet Obstruction, upper GI endoscopy.