Suctioning is a crucial element of airway treatment in severely ill patients. However, there are numerous hazards and issues involved. Trauma, hypoxemia, cardiac dysrhythmias, and, in the most extreme circumstances, cardiac arrest and death are examples. This document describes the current research guidelines for safer nursing suctioning procedures. The literature is reviewed through electronic databases; PubMed and Embase, for all related articles that were published in 2022. Showed, prior to suctioning, the following suggestions are made: patient assessment, patient preparation, and hyperoxygenation. Suctioning recommendations include catheter selection, insertion depth, negative pressure, duration of treatment, and number of suction passes. The usage of hyperinflation before and after suctioning was uncommon despite growing evidence that this method improves lung compliance.