Contact lens use has become more prevalent around the world and the associated ocular difficulties include microbial keratitis, redness, conjunctivitis, polymicrobial keratitis, contact lens-related corneal ulcer, and dry eyes. The use of an efficient multipurpose contact lens solution exhibiting a cleaning, disinfecting, lubricating, deproteinizing, and wetting effect would reduce the complications addressed by the use of contact lenses. Most of the currently available marketed formulations contain first-generation and second-generation antimicrobial agents having various drawbacks of corneal staining, antimicrobial resistance, etc. Medicinal plants have been used as a traditional treatment for ocular diseases for thousands of years in many parts of the world. Hence the use of herbal ingredients in these formulations could be promoted as they are more compatible with the human body, and has fewer side effects. This review explains contact lens induced microbial keratitis, multipurpose contact lens solution for its treatment, and various herbal medicines that are used for ocular disease treatment.