Electrophysiological characterization and functionality of neurons in murine cerebral organoids.

{"references": ["Ciarpella F, Zamfir RG, Campanelli A, Ren E, Pedrotti G, Bottani E, Borioli A, Caron D, Di Chio M, Dolci S, Ahtiainen A, Malpeli G, Malerba G, Bardoni R, Fumagalli G, Hyttinen J, Bifari F, Palazzolo G, Panuccio G, Curia G, Decimo I. Murine cerebral organoids develop network of functional neurons and hippocampal brain region identity. iScience. 2021; 24(12):103438. doi: 10.1016/j.isci.2021.103438."]}

Dataset includes patch-clamp recordings aim to characterize functionality of neurons belonging to murine cerebral organoids. Patch-clamp recordings were performed by University of Modena and Reggio Emilia unit (PI Prof. Curia Giulia). Organoids were generated by University of Verona unit (PI Prof. Decimo Ilaria) and transferred to Modena for electrophysiology experiments.

Related Organizations

University of Modena and Reggio Emilia
Italy
University of Verona
Italy

Keywords

Patch clamp; Sodium current; Potassium current; Firing properties; Brain organoids

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