Introduction : The aim of this study is to identify the determinants of arterial stiffness in a group of non-high risk patients. Material and Methods :A total of 310 asymptomatic and not-high cardiovascular risk patients (< 20%) aged between 20 to 74 years according to Framingham model had been enrolled and underwent measurement of the pulse wave velocity. Demographic data, cardiovascular riskfactors and hypertension or diabetes familial history have been analyzed. Results : 310 participants (41,83 ± 12.84 years ; 20-74 years) were included in the study. Mean pulse wave velocity (PWV) was 8.71 ± 1.77 m/s. The proportion of participants with abnormal arterial stiffness (increased PWV) was 19.03%. Our results indicate that age, hypertension especially when changing (developing) from 5 years, elevated diastolic arterial pressure and the physical inactivity have been associated to an increased probability of preclinical vascular disease. Conclusion : Determinants of this arterial involvement are : age ≥ 50 years, hypertension especially when changing (developing) from 5 years, elevated diastolic arterial pressure and the physical inactivity.