The public interest in cannabis for medical use is acknowledged, and anecdotal reports of effectiveness in individual patients are compelling. Our objective isto make overview of the current scientific papers for medicinal cannabis use in paediatric population. Literature review was conducted utilizing, PubMed, Medline, and Google Scholar. Cannabis based product have promising potential for add-on treatment of certain conditions in paediatrics. Well-designed Randomized Clinical Trials (RCTs) with sufficient number of patients are imperative to demonstrate benefit of therapeutic use. In paediatrics, the greatest evidence for medicinal cannabis useis for seizure disorders. RCTs have demonstrated the safety and efficacy of oral Cannabidiol (CBD) for treatment of seizures associated with Lennox-Gastaut or Dravet syndrome.