Asthma is a complex disease with a variable course. Biomarker research has expanded greatly with the advancement of molecular research techniques. A biomarker should be suitable to identify the disease as well the specific endotype/phenotype, useful in the monitoring of the disease and to determine the prognosis, easily to obtain with minimum discomfort or risk to the patient. An ideal biomarker should be suitable to identify the disease as well the specific endotype/phenotype, useful in the monitoring of the disease and to determine the prognosis, easily to obtain with minimum discomfort or risk to the patient - exhaled breath analysis, blood cells and serum biomarkers, sputum cells and mediators and urine metabolites could be potential biomarkers of asthma bronchiale. Presently an ideal biomarker doesn’t exist and the overlap between the biomarkers is a reality. Key words: Biomarkers, Bronchial asthma