Abstract Objective: To determine the prevalence of postpartum depression and its risk factors among Pakistani mothers. Methodology: This Cross-sectional study was conducted after ethical approval on a sample of 200 females of reproductive age (20-45years). Participants were selected through convenient random sampling on the basis of predefined eligibility criteria. Data were collected from primary and secondary healthcare facilities of district Sialkot using the Edinburg postnatal depression screening tool. Results: The mean age ±Std Dev of the participants was 28.09±5.346 years ranging from 20 to 45. The mean ±SD of the total score EPDS was found to be 3.53±5.72 with 87.50% of participants with scores below 13. Out of 200, 25(12.50%) females were candidates for postpartum depression. Conclusion: Postpartum depression screening helps recognition of the disorder. Postpartum depression among females of the target population is not negligible