Introduction: The most commonly given antibacterial drug worldwide is azithromycin. It belongs to the group of antibiotics known as macrolides. It is typically utilized in upper and lower respiratory tract infections,some sexually transmitted diseases,and severe bacterial infections due to its increased efficacy,tolerance,and broad-spectrum activity.Methods:Articles from the literature were examined to learn more about the risks and advantages of azithromycin. Results : Due to its low incidence of side effects, this is often marketed in solid, liquid, and ophthalmic formulations.Owing to its pharmacological and therapeutic qualities,it is also employed in the medication therapy for COVID-19. Conclusions: According to a review of the literature,there may be a higher risk of cardiac mortality, liver damage, ototoxicity, and hypersensitivity reactions. Keywords: Macrolides, Antibiotics, Azithromycin,QT prolongation,Ototoxicity