Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. Terfenadine, an H1-receptor antagonist antihistamine, is similar in structure to astemizole and haloperidol, a butyrophenone antipsychotic. The active metabolite of terfenadine is fexofenadine. The aim of present work was to develop fast dissolving tablets of Terfenadine by direct compression method using different binders Sodium starch glycolate, croscarmellose sodium and microcrystalline cellulose. The prepared tablets were evaluated for parameters such as hardness, friability, drug content, weight variation, in-vitro disintegration time, in vitro dissolution studies and stability studies. Disintegration Time of different prepared formulation F1, F2, F3, F4, F5 and F6 was found to be 105±4, 98±3, 95±5, 68±4, 43±2, and 55±1sec., the minimum Disintegration time was found in formulation F5 (43±2 sec.), select as optimized formulation.When the regression coefficient values of were compared, it was observed that ‘r2’ values of Higuchi release kinetics was maximum i.e.0.992 hence indicating drug release from formulations was found to follow Higuchi release kinetics. Keywords: Fast dissolving tablets, Superdisintegrants, Terfenadine, Crosspovidone, Sodium carboxy methyl cellulose. Direct Compression.