Our aim was to assess the risk of gastrointestinal (GI) hemorrhage associated with diabetes among patients taking low dose aspirin. As Aspirin is commonly used for treatment to migraine, pain, fever, or colds, and also for the prevention of cardio- and neurovascular disease, it's necessary to investigate the possible risk that an individual can have with its usage .Our study shows that people using low doses of aspirin had a higher risk of GI bleeding in patients with diabetes than those without diabetes. Hence, when treating diabetics with aspirin, the increased risk of GI hemorrhage should be taken in consideration. Keywords: low dose aspirin, gastrointestinal hemorrhage, Diabetes Mellitus, Risk Factor