The new developed pharmaceutical formulation is related to the fact that it is able to deliver the active substance to the target organ at therapeutically relevant levels, with negligible discomfort and side effects, increasing the patient compliance to the therapeutics. Regarding this respect, the route of administration is of major relevance. Various methods of Novel Drug Delivery systems are used for the better patient compliance. During the recent decades several studies have suggested that novel drug delivery systems based on lipid nanoparticles have the potential of increasing cutaneous drug delivery of both hydrophilic and lipophilic drugs. Despite the substantial potential of transdermal and dermal drug delivery, only relatively few drugs are yet commercially available as topical formulations. The limitation lies in the barrier function of the skin function, which is considered one of the most impermeable epithelia of the human body to exogenous substances. The current review gathered information on the, formulation, advantages, and disadvantages of Tablet in Tablet or compression coating. The report also elaborates on the importance of Tablets in Tablet techniques in the development of a modified release system. And information on capsule types, formulation, advantages and disadvantages. And various instruments required in the laboratory practices.