Antibiotic discovery, one of the greatest discoveries of mankind has saved countless lives. Despite their powerful action, their inadvertent and unregulated led to a global crisis known as antimicrobial/ antibiotic resistance. This has led to serious consequences as many susceptible bacteria are not responding well to even a high concentration of antibiotics. Although various strategies are implemented across the globe, concerted efforts are needed otherwise we will probably enter a post-antibiotic era where simple infections can kill humans or animals. On one end, newer promising antibiotics are not developed at the pace, we are misusing antibiotics on the other side. So, the present article in short describes antibiotic resistance and steps to carb down this problem at various levels of organizations