Background: Coronary CT angiography (CCTA), a non-invasive approach for detecting anatomic atherosclerotic disease, is a potential diagnostic tool for patients with chest discomfort.CCTA has several benefits over other modalities (such as physiologic testing), including better accuracy in diagnosing obstructive coronary artery disease, identification of high-risk disease, and detection of subclinical atherosclerosis. Objective: When opposed to stress testing, coronary CT angiography (CCTA) offers several advantages, including improved accuracy in detecting obstructive coronary disease. The studys goal was to conduct a systematic review and meta-analysis comparing CCTA to other standard-of-care (SOC) techniques in the assessment of patients suffering from acute chest discomfort. Methods: Authors began with recognizing the important examination proof that spots light on the significance of cardiac computed tomography for acute chest pain among patients presenting to the emergency department. We led electronic writing look in the accompanying data sets: Ovid Medline (2010 to present), Ovid Medline Daily Update, Ovid Medline in process and other non-filed references, Ovid Embase (2010 to present), The Cochrane Library (latest issue) and Web of Science. Just examinations in English language will be incorporated. The precise selection was acted in close collaboration with a clinical examination curator. Results: Ten studies with a total of 6285 patients were included in the study.The trials employed diverse definitions and methods for SOC, but they all used physiologic testing. There were no significant differences between the groups in terms of all-cause mortality (RR 0.48, 95 percent CI 0.17 to 1.36, p=0.17), MI (RR 0.82, 95 percent CI 0.49 to 1.39, p=0.47), or MACE (RR 0.98, 95 percent CI 0.67 to 1.43, p=0.92). However, the CCTA arm had substantially higher incidence of ICA (RR 1.32, 95 percent CI 1.07 to 1.63, p=0.01) and revascularization (RR 1.77, 95 percent CI 1.35 to 2.31, p0.0001). Conclusion: CCTA is related with similar significant adverse cardiac events as other SOC methods, but greater rates of revascularization in individuals with acute chest pain.