The objective of this study was to developed gastric floating drug delivery system containing Tinidazole and having a bulk density lower than that of gastric fluid and remaining buoyant on the stomach contents. In the Preformulation FTIR study was carried out for pure drug (Tinidazole), Tinidazole and excipients. It has not shown any interaction. Hence drugs were found to be compatible with excipients. The formulations were prepared by direct compression method. The angle of repose values for formulations ranges from 26.04±0.03 to 29.01±0.07. Bulk and tapped densities were used for the measurement of compressibility index. The bulk and tapped values for formulations range from 0.260±0.01 to 0.347±0.04 and 0.320±0.03 to 0.391±0.07 respectively. The carr’s index and hausner’s ratio values for formulations range from 13.12±0.03 to 16.52±0.01 and 1.08 ±0.05 to 1.19±0.06 respectively. Thus, all formulations exhibited good flow characteristics. From the study, concluded that F4 was the optimized formulation which has shown better buoyancy time 45sec and drug release 99.88% in 24hrs. However, further invivo studies can be carried out to support the results. Key words: Formulation, Optimization, Tinidazole, Floating tablets