Oral drug delivery is the most widely used route of drug administration among all the routes that have been explored for the systemic delivery via various pharmaceutical products of different dosage forms. Aim of the present work is to formulate the indomethacin tablets to present it in the form of. To develop and over an extended period of time in the gastro intestinal track and compared the in-vitro dissolution profile with that of the marketed product. It was deduced that MDTs of Indomethacin formulated by direct compression method. The superdisintegrants were used in formulation to ameliorate the disintegration of tablets. It produces better patient compliance and effective therapy of tablets. Also, the bitter drug can be easily formulated as mouth dissolving tablets by masking their taste using aspartame as taste masking agent. It was also found that the superdisintegrants are effective at an optimum concentration, on increasing the ratio of Crospovidone and Sodium starch glycolate concentration above their optimum concentration this enhance the gelling effects of formulation. The formulation TC7 exhibited better results as compared to other formulations. Further these formulations can be select for in vivo study. Key words: Formulation, Optimization, Mouth Dissolving Tablets, Indomethacin, Solid Dispersion