A drug utilization review of a population’s drug use to determine effectiveness, potential risks, drug interaction issues, and other issues. It aims to give doctors recommendations for the rational use of drugs, reducing side effects, polypharmacy, and exposure to potent drugs. With this study, we hope to provide a basic understanding of the illness and draw attention to the fact that improper use of anti-diabetic medications can result in poor patient outcomes and significant wastage of money and resources. Background: In recent years, India has seen a rapidly exploding epidemic of diabetes, and it presently holds the world record for having the most diabetic people in one nation. In view of this situation, drug utilization review of anti-diabetic medicines in the Indian healthcare environment has a valid significance to promote rational drug use in diabetics. Objective: This study aimed to identify the demographic information about the patients and to examine prescription trends for antidiabetic medications, as well as the distribution of adverse drug reactions, diabetes complications, and co-occurring diseases. Methodology: A retrospective observational study was conducted. Conclusion: The use of anti-diabetic drugs was almost found to be rational. The Pharmacist is the key person for improved therapeutic management based on the stage and condition of the patient. Keywords: Drug Utilization, Prescription Pattern, Insulin, Hypertension, Anti-diabetic drugs.