Regional simulation of ozone dry deposition is an important tool for understanding ozone pollution threats and quantifying the ozone impact on terrestrial ecosystems. In this study, we evaluate ozone dry deposition in the Yangtze River Delta (YRD) region using two different dry deposition schemes. The WRF-Chem model, Wesely dry deposition scheme, and revised Surfatm dry deposition scheme were used to simulate the ozone dry deposition process in the YRD region, and results are compared with the observation over a winter wheat field. The results show that the simulated ozone concentrations (cO3) of the two dry deposition schemes were good and lower than the measurements. The simulated ozone dry deposition velocity (Vd) in the Surfatm dry deposition scheme was more close to the measurements. The mean value of cO3 and Vd in the YRD region ranged from 30 to 50 nL·L−1 and from 0.2 to 0.5 cm·s−1 in the daytime, respectively. To improve the simulation results of the ozone dry deposition process, the simulation errors due to different land use types, the meteorological factors on dry deposition resistance functions, and the influence of chemical reactions must all be considered.